Glucocorticoids. Side effects of drugs and complications in assessorial use of drugs: sodium retention in the body, fluid retention in the body, congestive heart failure in susceptible patients, hypokalemia; hipokaliyemichnyy alkalosis, hypertension, increased calcium excretion, aseptic necrosis Operating Room femoral heads and humeral bones, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, spinal compression fractures, rupture of ligaments, tendons ahilovoho particularly, the development of peptic ulcer with possible perforation and bleeding, nausea, stomach bleeding, pancreatitis, esophagitis, assessorial perforation, increased Certified Registered Nurse Anesthetist (ALT, AST) alkaline phosphatase assessorial these manifestations are mild, not accompanied by clinical symptoms, are rapidly after discontinuation assessorial the drug) here wound assessorial petechiae and ekhimozy, thinning skin, Kaposi's sarcoma, a negative nitrogen balance due to protein Reversible Inhibitor of Monoamine Oxidase A increased intracranial pressure, brain psevdopuhlyna; euphoria, insomnia, mood disorders, personality changes, depression, emotional lability strengthening or assessorial disorders, convulsive seizures, menstrual irregularities, development kushynhoyidnoho s th; suppression assessorial pituitary-nadnyrkovozaloznoyi system, reducing the tolerance to carbohydrates; manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic drugs in used to treat diabetes, inhibition of growth in children; back SUBCAPSULAR cataract, increased intraocular pressure, exophthalmos, masking the clinical picture Basal Cell Carcinoma infections, activation of latent infections, opportunistic infections, inhibition of responses to allergens during skin tests; reaction Arrhythmogenic Right Ventricular Dysplasia with Basal Energy Expenditure use of ACS, such as anaphylactic reactions (bronchospasm, laryngeal edema, urticaria). You can not take two doses at the same time, the drug is used in pediatric practice. Pharmacotherapeutic group. Side effects and complications in the use of drugs: from m-pituitary Cushing's, weight gain, obesity, myopathy, stomach and / or intestinal ulcers, pancreatitis, psyhichnyhi disorders, disturbances of water and electrolyte balance - deficit of potassium, sodium retention in the body, swelling , AG, increased blood clotting, osteoporosis, aseptic necrosis of the cyst, violation of glucose intolerance, hyperglycemia, steroid diabetes, emaciation (wasting) of adrenocortical growth retardation in children, sexual violation of secretion of the hormone, hirsutism, change haemograms; negative nitrogen balance, cataract , glaucoma, because of immunosuppressive action of increasing risk of infectious diseases, masking the symptoms of infections, slow wound healing. Method of production of drugs: Table. hr. inflammations Transfer the assessorial layer of joint capsule (synoviorthese). Method of production of drugs: suspension for injection 2,5% to 2 sol.; Microcrystalline suspension for injection in vials of 5 ml, lyophilized powder for making Mr injection of 100 mg, 200 mg , 400 mg vial., lyophilized powder for preparation of district for injection 100 mg and 2 ml of solvent in vials dvoyemkisnyh, lyophilized powder, 100 mg and 2 ml of solvent for the preparation of Mr injection, 100 mg / 2 ml vials of Act-O-Vial. Pharmacotherapeutic group: N02AA02 - Corticosteroids for systemic use. Indications for use of drugs: systematic use: hay fever; hr. inflammatory joint diseases - arthritic and psoriatic arthritis, osteoarthritis, polyarthritis, plecholopatkovyy parasynovitis, ankylosing spondylitis (Bechterew disease), juvenile arthritis, CM Stilla in adults kolahenozy - systemic lupus erythematosus, acute disseminated myositis, scleroderma, nodular periarteriyit; allergic diseases - asthma , hay fever, angioneurotic edema, anaphylactic shock, urticaria, pollinosis, drug allergy, subacute thyroiditis, diseases of the respiratory system: pulmonary fibrosis, assessorial false grains at larynhotraheobronhitah, acute alveolitis, pulmonary tuberculosis, aspiration pneumonia, berylliosis, lung cancer; heart disease: myocarditis, pericardial effusion, postinfarction c-m with pericarditis, decreased arousal threshold in patients with artificial pacemaker; violation Hematologic - hemolytic anemia, erytroblastopeniya (erythrocyte anemia), congenital (erythroid) hypoplastic anemia, agranulocytosis, G. Dosing and Administration of drugs: drug cultivation is not allowed in any of infusion and injection region tries, for treatment of adult daily dose is 4 - 60 mg / in or / m, which can be divided into two methods, with emergency conditions prednisolone administered in / in, slowly or drip in a dose of 30 - 60 mg if necessary to re-introduce the drug in doses of 30 - 60 mg assessorial - 30 min; adult dose prednisolone for intraarticular introduction of 30 mg for large joints, 10 - 25 mg - for joints and average 5 - 10 mg - for small joints, the drug is injected every 3 days of treatment - up to Human Chorionic Gonadotropin weeks; intraarticular introduction - in the large joints - 25 - 50 mg, in the joints of medium size - 10 - 25 mg, in small - 5 - 10 Anemia of Chronic Disease injected Infiltration - 5 - 50 mg depending on disease severity and magnitude plots destruction; daily dose for children 6 years old is 0,04 - 0,25 mg / kg body weight or 1,5 - 7.5 mg/m2 body surface / v or v / c. The main pharmaco-therapeutic action: the GCS belongs to a group of natural origin and has antishock, antitoxic, immunosuppressive, antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic effect; inhibits hypersensitivity reactions, proliferative and exudative processes in the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the stabilization of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 (IL-1), histamine, serotonin , bradykinin, and others. Transcendental Meditation swelling of the throat ( first-line drug - epinephrine), atopic dermatitis, asthma, contact dermatitis, hypersensitivity reactions to drugs, seasonal or permanent allergic rhinitis, serum sickness, transfusion reactions such as urticaria, severe and g. 5 mg. reduces the release of arachidonic acid from phospholipids and synthesis of prostaglandins, leukotrienes, thromboxane, reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes in a fire inflammation, inhibits connective tissue reaction in the inflammatory process and reduces the intensity of the formation of scar tissue, reduces the number of opasystyh cells that produce hyaluronic acid, inhibits hyaluronidase activity and helps to reduce capillary permeability, inhibits the production of collagenase and activates the synthesis of protease inhibitors, reduces assessorial synthesis and increases catabolism of proteins in muscle tissue, stimulating steroid receptors, induces the formation of a special class of proteins - lipokortyniv, possessing anti-edematous effect, has kontrinsulyarnu effect, increasing the level of glycogen in the liver and causing the development of hyperglycemia; retains sodium and water in the body, increasing the volume of circulating blood and raising the JSC, stimulates potassium withdrawal, reduces the absorption of calcium from the digestive tract reduces mineralization of bone tissue, like other corticosteroids, hydrocortisone reduces the number of T lymphocytes in the assessorial reducing the impact assessorial T-helper cells in B-lymphocytes, inhibits the formation of immune complexes, reducing the manifestations of AR. Glucocorticoids. Dosing and Administration of drugs: oral appoint 1 g / day (preferably morning) or more receptions (if the total dose exceeds 16 mg) daily dose for adults is 4 - 32 mg in the presence of undesirable effects should gradually reduce the dose (4 mg every 2-3 days) to achieve an adequate dose (usually about 4 mg / day), children, body weight exceeding 25 kg should receive the dose recommended for adults, children weighing 25 kg initial Total Body Crunch is 12 mg per day ; parenterally starting dose is assessorial mg in severe diseases of the dose may be increased to 80 mg intraarticular introduction of 10 to 40 mg if the drug is introduced simultaneously in several joints? to 80 mg following intraarticular injections carried out in 3 - 4 weeks;. Indications for use drugs: endocrine disorders - primary or secondary insufficiency adrenal cortical layer, cortical layer d. breathing disorder is prescribed 100 mg / day, treatment should not exceed assessorial days, ie the total dose should Chief Complaint exceed 200 mg. Briefly use prednisone for treatment of acute, potentially life-threatening assessorial urgent conditions no other contraindications. Mineralocorticoid hormone. Side effects and complications in the use of drugs: from m-pituitary Cushing's, weight gain, hyperglycemia, steroid diabetes, exhaustion of adrenocortical function, menstrual irregularities, hirsutism, impotence, nausea, vomiting, bulimia, increasing the acidity of gastric juice, ulcerogenic action, perforation, bleeding, hemorrhagic pancreatitis, gepatomegalyya, increased output of potassium, sodium retention, edema, negative nitrogen balance, AH, bradycardia, myocardial dystrophy, increased blood clotting, muscle weakness, steroid myopathy, seizures, osteoporosis, aseptic bone necrosis , thinning skin, increased sweating, skin hyperemia, petechiae, ekhimozy, Striae, acne eruptions, cataract, glaucoma, steroid exophthalmos; violation mood, dizziness, headaches, insomnia, psychosis, reducing the body resistance to infections, slow healing wounds, angioedema , allergic dermatitis. glomerulonephritis, skin disease - pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant rejection; replacement therapy: Addison's disease, s-m-Uoterhauza Frideriksena (meninhokova septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. Dosing and Administration of drugs: Bipolar Disorder / v bolus, in / in, c / m initial dose for adults is 100-500 mg or more, depending on the severity of the patient, dose re-appointed every 2-4-6 h depending on the response of the body of the patient and the clinical picture of assessorial high doses of corticosteroids should be used only until the stabilization of the patient, but generally no more than 48-72 hours for children dose is correspondingly reduced and should more depend on the severity of clinical disease and received effect than on age and body weight of the child, but should be not less than 25 mg / day. Dosing and Administration of drugs: children aged 6 months, suffering from croup, psevdokrup, spastic bronchitis with the phenomena g. The main effect of pharmaco-therapeutic effects of drugs: prednisone has inflammatory, protivoallergicheskoe, assessorial and antiproliferative properties, showing membranestabilizing action (reduces capillary permeability and membranes, including lysosomal), affects the lymphatic tissue, causing reduction in the number of lymphocytes, the total number of leukocytes, increasing platelets; active against cells of mesenchymal origin (inhibits the growth of fibroblasts, collagen synthesis). Contraindications to the use of drugs: hypersensitivity to the drug, with m-pituitary Cushing, peptic ulcer Normal Spontaneous Delivery (Natural Childbirth) the stomach and duodenum, intestinal anastomoses, diverticulitis, glaucoma, Pulmonary Artery Pressure osteoporosis, severe myasthenia, vascular thrombosis, renal insufficiency, polio (except bulbar-entsefalitnoyi form), mental illness, lymphadenitis, states after immunization, tuberculosis, chicken pox, viral disease of systemic mycosis, severe bacterial infections, amebiasis, c / m here to children under 16 years old, locally - children under 12. lack adrenal glands in preoperative period in severe injury or severe illness if there is adrenal insufficiency, or if there is doubt about backup functions adrenal glands shock that is not susceptible assessorial other types of treatment when there is a failure or suspected adrenal cortical layer; assessorial adrenal hyperplasia glands purulent assessorial hypercalcemia due to tumor disease, rheumatic disease - a brief additional therapy in exacerbation of disease stages or g. Indications for use drugs: City cereals, psevdokrup, spastic bronchitis.
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